منابع مشابه
Viruses as Vectors and Gene Therapy
Molecular genetic studies over the last two decades have led to an enormous increase in our understanding of the molecular biology of replication of viruses. The complete nucleotide sequences of many viral genomes have been ascertained and detailed information on the origins of replication required for the replication of the viral genomes, the promoters used to express the information within th...
متن کاملAttenuated vesicular stomatitis viruses as vaccine vectors.
We showed previously that a single intranasal vaccination of mice with a recombinant vesicular stomatitis virus (VSV) expressing an influenza virus hemagglutinin (HA) protein provided complete protection from lethal challenge with influenza virus (A. Roberts, E. Kretzschmar, A. S. Perkins, J. Forman, R. Price, L. Buonocore, Y. Kawaoka, and J. K. Rose, J. Virol. 72:4704-4711, 1998). Because some...
متن کاملReticuloendotheliosis viruses and derived vectors for human gene therapy.
The reticuloendotheliosis viruses (REV) spleen necrosis virus (SNV) and reticuloendotheliosis virus strain-A (REV-A) are amphotropic retroviruses which infect a large variety of cells of avian and some mammalian species. They normally do not infect primate or rodent cells. However, they efficiently infect and integrate their genome into that of human cells when they are pseudotyped with the env...
متن کاملNovel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy.
Tissues from rhesus monkeys were screened by PCR for the presence of sequences homologous to known adeno-associated virus (AAV) serotypes 1-6. DNA spanning entire rep-cap ORFs from two novel AAVs, called AAV7 and AAV8, were isolated. Sequence comparisons among these and previously described AAVs revealed the greatest divergence in capsid proteins. AAV7 and AAV8 were not neutralized by heterolog...
متن کاملPolydnaviruses of Parasitic Wasps: Domestication of Viruses To Act as Gene Delivery Vectors
Symbiosis is a common phenomenon in which associated organisms can cooperate in ways that increase their ability to survive, reproduce, or utilize hostile environments. Here, we discuss polydnavirus symbionts of parasitic wasps. These viruses are novel in two ways: (1) they have become non-autonomous domesticated entities that cannot replicate outside of wasps; and (2) they function as a delive...
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ژورنال
عنوان ژورنال: Uirusu
سال: 1986
ISSN: 0042-6857,1884-3433
DOI: 10.2222/jsv.36.a1